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Text File  |  1987-10-07  |  533b  |  15 lines
  1.  
  2.          IN PATIENTS WITH RENAL IMPAIRMENT, PHENOBARBITAL DOSAGE
  3.          SHOULD BE CAREFULLY ADJUSTED TO AVOID TOXICITY (EXCESSIVE
  4.          SEDATION AND RESPIRATORY DEPRESSION).
  5.           
  6.          SOME CLINICIANS RECOMMEND THAT THE DOSAGE REGIMEN BE ADJUSTED
  7.          BASED ON THE PATIENT'S CREATININE CLEARANCE:
  8.           
  9.                      CREATININE
  10.                       CLEARANCE      DOSAGE INTERVAL
  11.                      (ML/MINUTE)
  12.           
  13.                         <10          12 to 16 hours
  14.           
  15.